South San Francisco

South San Francisco: Biotech Hub with Diverse Neighborhoods and Thriving Business Scene

South San Francisco, situated between San Francisco and Silicon Valley, is experiencing a surge in new residents attracted to its diverse range of neighborhoods. Prospective homeowners can choose from charming pre-war downtown cottages, expansive post-war mid-century suburbs, modern apartment complexes near transit hubs, and luxurious mini-mansions in Terrabay’s Mandalay Heights. Mandalay Heights, nestled in a small valley on the southern slope of San Bruno Mountain, offers bay views and homes designed with feng shui principles in mind, promoting harmonious energy flow.

Renowned as the birthplace of biotechnology since 1976 when Genentech opened its doors, South San Francisco stands as the country’s leading biotech hub. With over 200 biotech companies, including giants like Amgen, Stemcentrx, and 23andMe, and a staggering 11.5 million square feet of space dedicated to research and development (R&D), South San Francisco is at the forefront of drug and therapy applications, gene therapies, vaccine development, and medical device manufacturing.

The city’s rapid growth extends beyond biotech, attracting other tech leaders such as SAP (Successfactors) and serving as the headquarters for See’s Candies and Sanrio (parent company of Hello Kitty). Situated within close proximity to San Francisco and the Peninsula, South San Francisco has witnessed a boom in construction and development, with numerous office buildings and residential complexes springing up.

The thriving business sector has sparked a demand for supporting services and amenities. Downtown’s Grand Avenue reflects this shift, with long-standing family-owned businesses sharing space with trendy restaurants, a brewery and tap room, innovative recreational venues like bowling alleys and basketball courts, and trendy meeting spots such as Foundry & Lux. The city government’s partnerships with urban bicycle and carpooling apps like and have invigorated pedestrian street life. Furthermore, the opening of a new Business Costco last fall has provided a dedicated resource to support and supply the growing number of small businesses in South San Francisco.









1M - 1.8M


Pricing data based on single-family homes

Key features


Fourth-largest city

Being the fourth-largest city with a population of 66,980, it occupies a convenient position nestled between San Francisco and Silicon Valley.


Transportation options

Residents benefit from flexibility and easy access to a variety of transportation choices, such as BART, Caltrain, and the Ferry system.


Single family homes

Entry- and mid-level single-family homes; high-end bay view developments; brand-new downtown condominium communities


Easy commute

A hassle-free commute to San Francisco, whether by car, CalTrain, or BART.


Hiking trails

Residents of South City have the opportunity to explore San Bruno Mountain through hiking, take a leisurely stroll along the 2.8-mile Centennial Trail, or enjoy a section of the scenic San Francisco Bay Trail.


Biotech hub

The foremost biotechnology hub in the country.

Historic downtown

A historic downtown core undergoing revitalization.

South San Francisco Neighborhoods

Avalon Park: Classic 1950s Suburban Living in Convenient South San Francisco

Avalon Park is a timeless suburban neighborhood that emerged during South San Francisco's post-war growth in the 1950s. Situated just west of El Camino Real, the neighborhood boasts winding streets adorned with single- and two-story homes, reflecting the aspirations of a rapidly expanding city. Development began in the mid-1950s, with growth continuing for the next decade. Homes built during Avalon Park's early stages are generally smaller, with under 1,000 square feet of living space and more affordable price tags ranging from $700,000 to $900,000. Newer homes in the neighborhood feature two-car garages, two stories, and larger footprints exceeding 2,000 square feet, commanding prices up to $1.5 million in today's market. Avalon Park epitomizes quiet residential living, characterized by cul-de-sacs, well-maintained lawns, and two-car garages. Despite its serene atmosphere, the neighborhood enjoys a central location and convenience for commuters, shoppers, and diners. Highway 280, El Camino Real, BART, and Tanforan Mall are all within close proximity. Those seeking a blend of convenience, suburban serenity, and appreciation for the clean lines of 1950s subdivision architecture will find their desires fulfilled in Avalon Park.

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